Evaluating the Effectiveness and Feasibility of Reactive Focal Mass Drug Administration vs. Reactive Case Detection as a Community Level Intervention in Response to a Passively Identified Index Malaria Case in Swaziland
- Primary aim: To compare the impact of TPE (Targeted Parasite Elimination, fMDA) versus RACD (Reactive Case Detection) on malaria incidence.
- Secondary aims:
- To compare the impact of TPE versus RACD on seroprevalence.
- To compare the impact of TPE versus RACD on prevalence of infection.
- To compare the impact of TPE versus RACD on proportion of imported incident cases.
- To compare the impact of TPE versus RACD on time to first post-intervention incident local case.
- To compare the impact of TPE versus RACD on transmission potential as measured by relatedness of infections by microsatellite genotyping.
- To determine the feasibility of reaching 80% coverage for TPE versus RACD.
- To evaluate the safety of TPE versus RACD.
- To compare the acceptability of TPE versus RACD.
- To compare the costs and cost-effectiveness of TPE versus RACD.
- To measure the adherence to modified DOT regimen in the TPE arm.
Rationale and Abstract
ClinicalTrials.gov Identifier: NCT02315690
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
2014 Jan - 2017 Aug
Total Project Funding