A Phase I Study to Assess the Safety and Immunogenicity of ChAd63 ME-TRAP – MVA ME-TRAP Heterologous Prime-boost Vaccination Co-administered With EPI Vaccines in Gambian Infants

Objectives

Two vaccines, ChAd63 ME-TRAP and MVA ME-TRAP, were tested to see if they will form a safe and effective vaccination strategy against malaria. The vaccines had been found to be well tolerated when tested in Gambian adults, young children and infants, who are at risk of severe malaria. Both vaccines were given to participating infants at the same time as some EPI (Expanded Program on Immunization) vaccines, and assessed whether they were safe and still helpful in making the body’s defense system respond.

The study was conducted in collaboration with the Malaria Vectored Vaccines Consortium (MVVC)