Last Updated: 09/12/2024
Molecular basis of gamma delta T cell exhaustion during malaria
Objectives
The min goal of this study is to investigate the molecular mechanism of γδT cell exhaustion by microarray analysis using mouse malaria model.
Principal Institution
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Rationale and Abstract
Previous reports have shown that γδ T cells are important for the elimination of malaria parasites in humans and mice. However, how γδ T cells are involved in protective immunity against blood-stage malaria remains unknown. Recently it has been reported that repeated infection of Plasmodium falciparum associated with loss and dysfunction of Vδ2+γδ T cells. This study found candidates of the γδT cell exhaustion-associated molecules.
External reference
Date
Apr 2018 — Mar 2021
Total Project Funding
$40,673
Funding Details
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