Last Updated: 02/12/2025
Mechanisms of metformin-enhanced gamma delta T cell response during Plasmodium infection
Objectives
*Original title and text were machine translated from Japanese
This project investigated the novel effects of metformin, anit-diabetic drug, on the immune responses against Plasmodium parasites.
Plasmodium infection is one of the severe infections in the world. The immune responses against Plasmodium infection are impaired and enough immunological memory is not able to be established. It is important to research the way that enhance immune responses during Plasmodium infection. In mouse malaria model, it was found that metformin increased the number of gamma delta T cells. Metformin affect neither glycolysis nor mitochondrial respiration in gamma delta T cells although it has been reported that the drug regulates the metabolisms of hepatocytes and skeletal muscle cells. It was found that phosphorylation on S6 protein is up-regulated in gamma delta T cells. Therefore, the findings indicated the novel mechanism of metformin on proliferation of gamma delta T cells.
Apr 2016 — Mar 2019
$43,542
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