Last Updated: 27/10/2025
Bloodborne tropical pathogen detection using multiple nanophotonic arrays
Objectives
The overall goal of this project is to produce a field-ready diagnostic system which sensitively and simultaneously detects 6 major bloodborne tropical pathogens in unprocessed whole blood specimens. Upon these operating characteristics, in the R33 phase, the assay will be further developed by:
- Engineering and building an integrated testing unit suitable for field use
- Deploying the assay for pathogen detection in prospective cohorts of febrile patients at field sites in western Kenya and western Thailand.
In tropical settings, the diagnosis of infectious etiologies of fever remains challenging, owing to the complex epidemiology of parasitic, viral, fungal, and bacterial causes and the suboptimal performance of current diagnostics. Multiplex molecular pathogen detection systems are now routinely used in the developed world to interrogate respiratory and blood specimens, and there remains an ongoing need for simple, rapid, multiplex, and sensitive platforms for point-of-care diagnostics for tropical pathogens.
Duke Global Health Institute - Project detailsNIH project details
Dec 2015 — Nov 2017
$406,843
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