Last Updated: 14/07/2025
Analysis of membrane deforming proteins in malaria parasite
Objectives
*Original title and text were machine translated from Japanese
Malaria parasite live with erythrocyte and form parasitophorous vacuole (PV) around the parasite. And the parasite develops membrane trafficking system to get nutrients and transport many proteins. This project examined whether or not malarial proteins could participate in these membrane remodeling.
It was found that the candidate protein directly bound to liposomes and deformed them. The activity of membrane deformation by the protein was altered in the presence of GTP. This project is now investigating the detailed mechanism of membrane deformation by the protein using electron microscopy and high speed atomic force microscopy.
Apr 2017 — Mar 2020
$43,696
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