Last Updated: 27/03/2026
Analysis of effects of lipids on function and structure of membrane proteins
Objectives
This project will investigate the effect of cardiolipin on transport activity of yeast and malaria parasite mitochondrial carriers.
Principal Institution
Principal Investigators / Focal Persons
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Rationale and Abstract
In this study, by using mitochondrial carriers and a lipid, cardiolipine, which is known to interact with the mitochondrial carrier, as a model membrane protein-lipid system, it clarified roles of lipids against the function and structure of the membrane protein. As a result, it was clarified that addition of cardiolipin increases the transport activity of the mitochondrial carriers localized in mitochondrial membrane, but such a effect was not observed in the mitochondrial carriers present in other membrane systems.
External reference
Themes
Date
Apr 2015 — Mar 2018
Total Project Funding
$44,893
Funding Details
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