Last Updated: 02/08/2024
Transcriptional control mechanism of malaria parasite sporozoite stage centered on master transcription factor AP2-Sp
Objectives
*Original title and text were machine translated from Japanese.
This study aims to elucidate the overall picture of the transcriptional control mechanism during the process from sporogony to the liver stage, based on the results of the technical improvements of the ChIP-seq method that the applicant has advanced so far.
Sporozoites are the first stage of malaria parasite infection in humans and are important targets for vaccines and drugs. Sporozoites form within oocysts on the mosquito midgut and then invade the salivary glands. Sporozoites that invade the salivary glands are released by the mosquito’s blood meal, reach the liver, and become the blood-infected stage. The genes expressed at this stage are classified into groups that function in various processes such as sporozoite formation (sporogony), salivary gland invasion, and liver infection.
Apr 2023 — Mar 2026
$34,916
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