Last Updated: 10/07/2025
The interaction between GAMA and MSP10 plays an important role in P.falciparum erythrocyte invasion
Objectives
*Original title and text were machine translated from Japanese
This research project aims to elucidate the functions of P. falciparum MSP10 and GAMA.
These proteins, that expressed by the merozoites, the invasive form malaria parasite, may be involved in erythrocyte invasion. First, MSP10 and GAMA were each synthesized as five and eight truncates, used is raise antibodies in rabbits, an subsequently the antibodies were used for growth inhibition tests against P. falciparum. As a result, C terminal region of GAMA were observed to have invasion inhibitory activity as well as the N terminal region of MSP10. In conclusion, This study consolidates the new approaches towards optimization of vaccine candidates antigen discovery.
Apr 2017 — Mar 2019
$37,512
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