Last Updated: 07/05/2026
The correlation between the structure of PyGM75 and the function in exflagellation of microgamete
Objectives
This project investigated whether the molecular structure of protease-like domain and transmembrane domain of PyGM75 is involved in PyGM75 function in the exflagellation of microgametes in Plasmodium yoelii.
PyGM75 expressed on the male gamete surface of Plasmodium yoelii functions in exflagellation of microgametes. The transgenic parasite lacking the transmembrane region of pygm75 did not express the PyGM75 on the surface of male gametes. Furthermore, the infectivity to mosquito (the number of oocysts) was decreased compared to the wild type. These results suggested that the transmembrane domain of PyGM75 at C-terminal is important for the expression of PyGM75 on the male gamete and the ability to infect mosquitoes.
Apr 2015 — Mar 2018
$42,591
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