Last Updated: 18/06/2024
Studies on the role of Plasmodium-specific Tr27 cells in infection regulation and on their antigen recognition
Objectives
*Original title and abstract were machine translated from Japanese
This study is a basic study that uses a mouse model of malaria parasite infection to analyze the characteristics of cells involved in immunosuppression. In particular, the focus will be on the regulatory T cells that produce the cytokine IL-27 discovered by the principal investigators, and the relationship between Tr27 cells and other cells in immune control during the course of infection will be studied, as well as the recognition of malaria parasites by Tr27 cells. Also, the differences between antigens and antigens recognized by other T cells will be clarified
Malaria is an important infectious disease that infects more than 200 million people and causes nearly 500,000 deaths every year. However, a sufficiently effective vaccine has not been obtained. In chronic infectious diseases such as malaria, the host’s immune response is modified and suppressed during infection, and sufficient immune defense and immune memory are not established. Therefore, in order to overcome chronic infectious diseases such as malaria, it is important to elucidate these immune modification mechanisms. The Tr27 cells that were discovered are T cells that control immunity during infection, and are thought to moderate immune responses in systemic infections such as malaria. A better understanding of these cells will provide important information for the development of the next generation of innovative vaccines.
Apr 2019 — Mar 2022
$158,292
Related Resources
