Last Updated: 22/12/2025
Induction mechanisms and the regulatory roles of IL-27-producing regulatory T cells during malaria infection
Objectives
*Original title and text were machine translated from Japanese
This project aimed to study antigen recognition of Tr27 cells, mechanisms underlying their induction and their regulatory roles during infection.
Malaria patients are known to exhibit reduced immune responses, although its mechanisms are unknown. Using a mouse model, it was previously reported CD4+ T cells that inhibit the immune responses in IL-27 dependent manner during malaria infection, and named them Tr27 cells. Data suggested that specific Th1 cells and Tr27 cells recognize distinct Plasmodium antigens. Furthermore, we produced a mouse model to monitor IL-27 expression with a fluorescent protein and conditional gene knock-out mice that lack IL-27 in specific cell populations. These tools are powerful in studying the induction and function of Tr27 cells during infection with malaria parasites.
Apr 2016 — Mar 2019
$158,891
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