Last Updated: 13/11/2025
School-Based Treatment With ACT to Reduce Transmission (START-IPT)
Objectives
The primary objective of the study is to evaluate the impact of IPT for malaria in schoolchildren using monthly DP, as compared with the current standard of care (no IPT), on measures of malaria transmission in community members.
The secondary objectives are:
(1) To evaluate the impact of IPT for malaria in schoolchildren, as compared with no IPT, on clinical malaria indicators in schoolchildren.
(2) To evaluate the impact of IPT for malaria in schoolchildren on the risk of serious adverse events, and absences from school.
(3) To identify best practices and challenges for integration of health programmes into schools in Uganda and other low-resource settings.
(4) To identify potential supporting intervention methods and content of messages for the integration of monthly IPT into schools in Uganda.
The hypothesis that malaria transmission, as measured by the prevalence of asexual parasitaemia, will be lower in communities surrounding the intervention schools, than those surrounding the standard care schools will be tested.
London School of Hygiene and Tropical Medicine (LSHTM), United Kingdom
The project proposes to evaluate the community-level impact of intermittent preventive treatment (IPT) for malaria in schoolchildren on clinical outcomes and malaria transmission, using a cluster-randomised design in Jinja, Uganda. Dihydroartemisinin-piperaquine (DP) will be administered to schoolchildren monthly for up to six rounds of treatment during one school year. Outcomes will be measured using surveys of communities, schoolchildren, and mosquito vectors. This proposal also includes health service research to evaluate the potential feasibility of taking the programme to scale, which will guide future research and implementation of the intervention, and help shape policies in Uganda and elsewhere in Africa.
ClinicalTrials.gov Identifier: NCT02009215
| Study Type : | Interventional (Clinical Trial) |
| Allocation: | Randomized |
| Intervention Model: | Parallel Assignment |
| Masking: | None (Open Label) |
| Primary Purpose: | Prevention |
Lancet Glob Health. 2018; Assessment of community-level effects of intermittent preventive treatment for malaria in schoolchildren in Jinja, Uganda (START-IPT trial)Malar J. 2019; Intermittent preventive treatment of malaria delivered to primary schoolchildren provided effective individual protection in Jinja, Uganda
Clinicaltrials.gov - Trial detailsUK Research _& Innovation - Trial details
Jan 2014 — May 2015
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