Portable diagnostics for disease and drug resistance with focus on malaria and bacterial infections

The proprietary novel tool consists of a combination of two recently developed methods. Cell-phone based fluorescence microscopy will be used to replace expensive standard fluorescence microscopy and to enable the widespread use of our diagnosis platform. The fluorescence microscope will be used to directly visualize fluorescent patterns along individual DNA molecules stretched in nanofluidic channels. With each molecule analyzed individually, no cell culturing nor any DNA amplification is necessary.The work will take place in an international collaboration. There are collaborators at Glasgow University who are well-known specialists in parasitology and collaborators at Karolinska that are experts in infections by bacteria resistant to antibiotics. For the development of the cellphone based fluorescence microscope the researchers will collaborate with a group at UCLA who is the leading pioneer of simple to use and low-cost alternatives to standard microscopy. To ensure that this technology will be designed with the end-user in mind and during the later phase of the project tested under realistic conditions, researchers will engage several researchers who are stationed in the affected countries in Africa and Asia.

Project details

Diagnostics
Drug Resistance
Genetics and Genomics
Product Development

Jan 2017 — Dec 2019

$328,149

Sweden