Last Updated: 12/03/2026
P. Falciparum Infection Dynamics and Transmission to Inform Elimination (INDIE-1a)
Objectives
This study aims to quantify the impact of enhanced community case management (CCM) and monthly screening and treatment (MSAT) on the trajectory of infections experienced by the participating individuals, gametocyte production in these infections and transmissibility to mosquitoes.
London School of Hygiene and Tropical Medicine (LSHTM), United Kingdom
Study Type: Interventional (Clinical Trial)
Actual Enrollment: 907 participants
Intervention Model: Parallel Assignment (cluster randomized trial)
Masking: None (Open Label)
In total, 180 compounds in Saponé, Burkina Faso, will be randomised to one of three interventions:
- Arm 1: current standard of care with passively monitored malaria infections.
- Arm 2: standard of care plus enhanced CCM, comprising active weekly screening for fever, and detection and treatment of infections in fever positive individuals using conventional rapid diagnostic tests (RDTs).
- Arm 3: standard of care and enhanced CCM, plus monthly screening and treatment (MSAT) using RDTs.
The study will be conducted over approximately 18 months covering two high transmission seasons and the intervening dry season.
Published Protocol: Investigating the impact of enhanced community case management and monthly screening and treatment on the transmissibility of malaria infections in Burkina Faso: study protocol for a cluster-randomised trialArticle: Effect of weekly fever-screening and treatment and monthly RDT testing and treatment on the infectious reservoir of malaria parasites in Burkina Faso: a cluster-randomised trial
Asymptomatic Reservoir
Drug-based Strategies
Impact of Interventions
Measurement of Transmission
Aug 2018 — Feb 2020
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