Novel Insecticides: structure activity relationships of a formamidine octopamine receptor agonist with mosquitocidal activity

Vector-borne diseases, especially those such as malaria and dengue fever have an enormous impact on the United States Military and human morbidity and mortality worldwide. Vector management has a proven track record in the control of insect-transmitted disease in human populations; unfortunately, the keystone of this control, insecticide treatment, is no longer effective in some areas due to development of resistance. The octopaminergic system is involved in a variety of essential insect physiological processes and is essentially absent in vertebrates, making this pathway an attractive target for insecticide development. The aim of this project will be achieved by 1) performing a structure activity relationship study to enhance stability, increase lipophilicity, and reduce mammalian toxicity; and 2) assess the physiological response of mosquitoes olfaction and behavior to formamidine analogs. 

Product Development
Vector Control

Jun 2016 — Jun 2018

$424,875

United States

Larval source management