Last Updated: 02/12/2024
A novel approach to identify the specific antibody characteristics important for protection from malaria in pregnant women
Objectives
To determine which naturally-acquired or vaccine induced antibodies protect pregnant women from malaria, and how variation in VAR2CSA sequences affects this protection.
Antibody protects against malaria, but the specific characteristics of protective antibody are unknown. Pregnant women lack antibody to parasite protein called VAR2CSA, explaining their malaria susceptibility. Using samples from vaccine trials and clinical studies in pregnant women, and a ‘Systems Serology’ approach, we will determine which naturally-acquired or vaccine induced antibodies protect pregnant women from malaria, and how variation in VAR2CSA sequences affects this protection.
Article: Developing a multivariate prediction model of antibody features associated with protection of malaria-infected pregnant women from placental malariaArticle: Poor Birth Outcomes in Malaria in Pregnancy: Recent Insights Into Mechanisms and Prevention Approaches
Jan 2018 — Dec 2021
$728,162
Related Resources
