Modelling the public health impact and cost-effectiveness of the RTS,S malaria vaccine in malaria endemic countries

Objectives

The aim of this project is to estimate the public health impact and cost-effectiveness of introduction of the RTS,S/AS01 malaria vaccine through:

1. Model-based analysis of Phase II and Phase III trial data;

2. Simulation of impact using an existing malaria transmission model taking into account variation in prevalence, ITN usage, access to first-line treatment and a range of vaccine introduction dates;

3. To estimate the cost-effectiveness of the vaccine compared to other ongoing interventions.