Last Updated: 21/07/2025
Mechanism of plasma exosomes of Plasmodium infected mice inhibiting angiogenesis in lung cancer
Objectives
This project aims to investigate how plasma exosomes from Plasmodium-infected mice inhibit angiogenesis in lung cancer, specifically focusing on the types of cells producing these exosomes, their inhibitory components, and the mechanisms involved.
Guangzhou Institutes of Biomedicine and Health (GIBH), China
Cancers are important life-threating diseases, and some pathogen infections could inhibit the cancer progression. In previous studies, it was discovered that the plasma exosomes of Plasmodium Py17XNL (Py) infected mice significantly inhibited Lewis lung cancer (LLC) growth and tumor angiogenesis in the tumor-bearing hosts. Further study indicated that these exosomes affected the signal transduction of angiogenesis in endothelial cells. However three scientific questions have not been elucidated yet: what kind(s) of cells produce these exosomes? What components inhibit the angiogenesis? Why these exosomes and their components inhibit the angiogenesis? This proposal could potential give answers to these questions through a Py-infected LLC-bearing mouse model study. Following techniques will be used in this study: flowcytometry, deep sequence of mRNA and miRNA, proteomics and experiment confirmation. The key molecules in angiogenesis signal transduction will be measured. On one hand, this effort may clarify the mechanisms of action for malaria inhibiting cancer angiogenesis, providing more laboratory evidence for the clinical study. On the other hand, this work may benefit for the development of new anti-tumor therapies targeting angiogenesis based on the exosome components.
Jan 2017 — Dec 2020
$86,831
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