Last Updated: 05/04/2024

Managing insecticide resistance in Burkina Faso and Côte d’Ivoire (REACT): researches on new vector control strategies


The objectives of this project are:

  • To perform a Phase III randomized controlled trial of new vector control tools in combination with Long Lasting Insecticidal Nets (LLINs). The study will evaluate the benefit to use 1) insecticidal paints, 2) larvicides, 3) Ivermectin for both human and domestic animals and 4) a strengthened information, education and communication strategy to complement the universal coverage with LLINs through a cluster randomized trial.
  • To assess the efficacy of each combination against malaria transmission, prevalence, and incidence.
  • To assess the efficacy of each combination to manage insecticide resistance.
  • To characterize the residual transmission and to assess its determinants.
  • To study the behaviour of old, infectious and resistant Anopheles.
Principal Investigators / Focal Persons

Cédric Pennetier

Study Design

Outcome measures:

  • Primary outcome: malaria incidence (continuous monitoring during 2 years)
  • Secondary outcomes: entomological inoculation rate and malaria prevalence Identifier: NCT03074435 

Study Type  : Interventional  (Clinical Trial)
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention

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