Last Updated: 02/09/2025
Insecticide treated eave nets and window screens for malaria control
Objectives
To propose a new tool – purpose made insecticide-treated eave nets (ITENs) with insecticide treated window screens (ITWS) for full house screening.
Specific objectives:
- To compare the household and community protective efficacy of 2 ITEN and ITWS products with different insecticides in local conditions to see which is better to take forward to a large scale trial.
- To assess ease and cost of fitting, longevity and community acceptability by fitting 200 local houses with ITENs and ITWS and follow up after 1 year.
London School of Hygiene and Tropical Medicine (LSHTM), United Kingdom
We will conduct an efficacy study of 2 ITENs and ITWS against local mosquitoes. We will use the Ifakara semi-field site, comprising 4 experimental huts, each in its own enclosure. Volunteers sleep in the huts and mosquitoes are introduced into the enclosures. The following morning, the mosquitoes are assessed in terms of mortality, blood feeding and hut entry. The two ITENs to be tested are 1) the insecticide deltamethrin together with the synergist piperonyl butoxide PBO 2) the insecticide clothianidin; both of which are effective against resistant mosquitoes. The other 2 huts will be controls: one will be a negative control with no insecticidal intervention to ensure experimental validity; in the other, the sleeper will use a LLIN treated with deltamethrin and (PBO) for comparison with the standard of care. An experiment will last 4 weeks. In the first week, each of the huts will be randomly assigned to one of the 4 arms. For 4 nights, 60 (30 anopheles and 30 aedes) mosquitoes will be released into each enclosure each night and the outcomes will be recorded the following morning. Then the 4 interventions will be rotated between the 4 huts in a Latin square design and after 3 nights’ washout the procedure will be repeated until each intervention has been in each hut. During the 4 nights each week, the sleepers will be rotated between huts. The experiment will be done 6 times, with new ITENs and ITWS then with artificially aged ones to approximate 1, 2, 3, 4 and 5 years of field use.
We will conduct a second study on feasibility and acceptability. We will put up ITENs and ITWS in 200 houses in local villages to demonstrate that they can easily fitted and learn lessons of how to do this in the local environment. At baseline, we will conduct a survey on acceptability and attitudes to the products. We will follow up 1 year later and ask acceptability. In the one year survey we will assess the proportion of products still in place, and the condition of the products.
Jan 2020 — Nov 2022
$274,264
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