Improving the efficacy of malaria prevention in an insecticide resistant Africa - Collaborative Award
This study will be conducted in a region of Burkina Faso, chosen to represent the potential future of malaria transmission in Africa (high LLIN coverage, high levels of pyrethroid resistance, and stubbornly persistent levels of malaria infection in the population), with the following aims:
1. To quantify the level of protection provided by LLINs in an insecticide resistant Africa through renewal of mathematical models of malaria transmission to incorporate empirical data on the ecology and behaviour of insecticide resistant vectors.
2. To identify cost effective, complementary interventions that would drive malaria transmission towards zero. We will achieve this using a trans-disciplinary approach, including entomology, epidemiology, mathematical modelling and economics, to address the following specific research questions:
- What are the risk factors associated with malaria infection in children in a rural district of Burkina Faso?
- How do physiologically and behaviourally resistant mosquito populations limit LLIN performance?
- What are the patterns and determinants of LLIN use and access to treatment?
- What combination of interventions will be most effective in driving malaria to zero?
- What is the most cost effective and affordable package of malaria prevention tools?