Last Updated: 03/10/2025
Identification of adhesive proteins on the surface of erythrocytes infected with Plasmodium falciparum gametocytes
Objectives
The aim of this study is to clarify how immature gametocytes are sequestered in the bone marrow by focusing on a parasite membrane protein called SBP1 that is localized in the “Maurer’s cleft,” which serves as a relay point for transporting adhesion proteins to the surface of infected red blood cells.
Plasmodium falciparum differentiates into a special form called a “gametocyte” to reproduce sexually inside the mosquito. This gametocyte remains in the bone marrow while immature and appears in the bloodstream when mature. By searching for molecules that appear on the surface of gametocyte-infected red blood cells via SBP1, we aim to elucidate the mechanism by which gametocyte-infected red blood cells adhere to bone marrow cells.
Apr 2025 — Mar 2028
$30,034
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