High throughput evaluation of membrane feeding assays for the evaluation of malaria transmission blocking vaccines and naturally acquired transmission-blocking immunity: Statistical model for SMFA precision

Objectives

This project aims to develop a mathematical method to guide the interpretation of SMFA data.

The specific objective is to determine the number of mosquitoes that have to be examined for different research questions and the variability in mosquito infection prevalence between feeders filled with blood from the same gametocyte donor. The latter will be important for sample size considerations.