Last Updated: 12/02/2018
Evaluation of a novel Long Lasting Insecticidal Net and Indoor Residual Spray product
Objectives
The proposed study is a four-arm randomized control trial (RCT) in 48 villages in the Lakes region in Tanzania comparing the relative effectiveness of 4 vector control interventions for reducing malaria transmission and controlling vector populations in an area where An gambiae s.s is pyrethroid and carbamate resistant:
- a standard long-lasting insecticidal net (LLIN),
- an LLIN which incorporates a piperonyl butoxide (PBO) synergist,
- a long-lasting indoor residual spray (IRS) formulation used in conjunction with standard pyrethroid LLIN or
- the long lasting indoor residual spray (IRS) formulation used in conjunction with the LLIN which incorporates a PBO synergist.
The trial will provide epidemiological, entomological, economic and social evidence of impact, as the investigators shall be measuring the reductions in malaria prevalence and malaria transmission rates EIR, and changes in the frequency of resistance, mosquito species ratios and economic cost-effectiveness.
The proposed trial will demonstrate whether the novel LLIN and long lasting IRS formulation will be more effective for controlling An.gambiae s.s. and reducing malaria prevalence than current practice with the conventional LLIN.
Progress in malaria control is under threat by wide-scale insecticide resistance in malaria vectors. Two recent vector control products have been developed: a long-lasting insecticidal net that incorporates a synergist piperonyl butoxide (PBO) and a long-lasting indoor residual spraying formulation of the insecticide pirimiphos-methyl.
ClinicalTrials.gov Identifier: NCT02288637
| Study Type : | Interventional (Clinical Trial) |
| Allocation: | Randomized |
| Intervention Model: | Factorial Assignment |
| Masking: | Single (Participant) |
| Primary Purpose: | Prevention |
Sep 2014 — Apr 2018
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