Efficacy and safety of DHA-PIP for the treatment of uncomplicated Plasmodium falciparum malaria and chloroquine for the treatment of Plasmodium vivax malaria in Yunnan, China

Malaria is caused by infection of blood cells with Plasmodium parasites. People with malaria feel unwell and typically have fever, tiredness, vomiting, and headaches. Malaria can lead to death, and if not treated, it can cause repeated bouts of illness. The World Health Organization (WHO) recommends artemisinin-based combination therapy (ACT) for the initial treatment of malaria with no complications caused by Plasmodium falciparum. Chloroquine is recommended for treatment of Plasmodium vivax malaria. However, there have been reports of resistance of the parasite infection to treatment with these drugs in countries such as Myanmar, Thailand, Vietnam and Cambodia that border China. 

Based on the fact that “suspected resistance” and “confirmed resistance” of falciparum malaria to ACT arose and spread in South-east Asian locations, such as Myanmar, Thailand, Viet Nam and Cambodia, it is important to continuously monitor the efficacy of DHA-PIP in these sites and neighbouring areas and to monitor its distribution or spread in Yunnan. Additionally, more studies are needed to confirm the relationship of some K13 mutations with anti-malaria drug resistance.

• Study design: Observational surveillance study

• Primary study design: Observational

• Secondary study design: Cross sectional study

• Trial setting: Hospitals

• Trial type: Treatment

Project details

Drug-based Strategies

Jun 2012 — Dec 2016

China