Last Updated: 07/07/2025
Development of a new infectious disease control method targeting paired receptors
Objectives
*Original title and text were machine translated from Japanese
This study analyzed how the Leukocyte Immunoglobulin-like Receptor (LILR) family is involved in host-pathogen interactions in viral infection, malaria infection, and bacterial infection which will be helpful to develop new targeted infection control strategies.
Paired receptors are a series of receptors consisting of activated and suppressed receptors, are widely expressed in immune cells, and have an important function in controlling immune responses. It has been shown that suppressed paired receptors are important for the control of immune response, but they are also used for immune escape mechanism of pathogens such as virus and malaria parasite. It has also been clarified that the activated paired receptor plays an important role in biological defense by recognizing a pathogen that has acquired an immune escape mechanism. This study elucidates the new immune escape mechanism and infection defense mechanism by pathogens, and is expected to develop new preventive and therapeutic methods for infectious diseases targeting paired receptors. This project will analyze the ligand molecules of pair-type receptors of pathogens such as viruses, bacteria, and malaria parasites, elucidate the immune escape mechanism of pathogens and the host defense mechanism of host immunity, and develop infection control methods targeting pair-type receptors.
Apr 2017 — Mar 2020
$543,790
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