Development of a malaria hot-spot surveillance system

A panel of serological markers capable of detecting recent exposure to P. vivax infection has recently been identified and validated, thereby allowing for the indirect identification of malaria hot-spots. To achieve this, 307 P. vivax proteins were screened for their ability to induce IgG responses in P. vivax-exposed individuals across Thailand, Brazil, and Papua New Guinea. The kinetic profile of these responses was determined over a 9-month period in the absence of recurrent infections. Candidate markers were down-selected based on high immunogenicity at the time of infection, comparable antibody longevity between the three sites, and low levels of individual variation in IgG responses. Finally, 55 down-selected proteins were established as the sero-marker candidates for malaria hot-spot surveillance.

Project Details

Immunology
P. vivax
Surveillance

Apr 2015 — Mar 2018

$142,751

Brazil
Papua New Guinea
Thailand