Last Updated: 02/12/2024
Development of next-generation vaccine that shows protective effect against malaria antigen mutant strain based on original vaccine
Objectives
*Original title and abstract were machine translated from Japanese
This study investigated whether the original vaccine produced by the project also attenuated the vaccine effect against malaria protozoa strains with mutations in the PfCSP antigen, which was clarified in the clinical trials of the preceding vaccines RTS, S using the PfCSP antigen.
This project will verify and evaluate the improvement and efficacy of this vaccine against it. Specifically, the project will prepare a humanized transgenic mouse malaria protozoan library into which a specific point mutation has been introduced, conduct an infection experiment on mice immunized with this vaccine, and identify a mutation that attenuates the vaccine effect. It will efficiently identify the antigenic variation of Plasmodium malaria that attenuates the vaccine, and establish a method for rapidly developing a vaccine that can respond to the antigenic variation.
Apr 2022 — Mar 2025
$38,278
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