Last Updated: 14/07/2025
Analyses of lipid recycling and phospholipid variety induction mechanisms in Plasmodium falciparum-infected erythrocytes
Objectives
*Original title and text were machine translated from Japanese
This project focused on understanding the lipid remodeling system to understand mechanisms to establish an infected cell environment by Plasmodium parasites.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
By adding deuterated fatty acid to the cell culture, we found that parasites incorporate particular fatty acids including palmitic acid, but the combinations of two fatty acids are limited. In addition, it was observed that gametocytes showed faster turnover of incorporating fatty acids. This quick remodeling of phospholipids was more evident in PE. These observations suggested that Plasmodium parasite controls stage-specific lipid profile.
External reference
Themes
Date
Apr 2017 — Mar 2020
Total Project Funding
$42,517
Funding Details
Country / Project Site(s)
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