Last Updated: 04/04/2024

An integrated approach to clinical trials, capacity building and networking in West Africa (WANECAM)

Objectives

The primary objective of this clinical study was to compare the incidence rate of uncomplicated malaria episodes in children and adults treated with repeated ACT therapy over a period of two years. In this three arm study PA and DHA-PQP is compared to either ASAQ or AL (depending on the site location).

The secondary objectives of this study were:

  1. To compare PCR corrected and uncorrected ACPR at D28 and D42 (as defined by WHO 2009 protocol) between the ACT treatment arms
  2. To compare re-infection and recrudescence rates over 42 days between the ACT treatment arms
  3. To compare FCT and PCT between the ACT treatment arms
  4. To compare gametocytes carriage and density between the ACT treatment arms
  5. To compare time to the second infection and re-infections between treatments arms
  6. To assess and compare safety of the three ACTs in repeated therapy.
Study Design

Study type: Interventional

Allocation: Randomized

Phase: IIIb/IV

Masking: Open (masking not used)

Primary purpose: Treatment

Trial Number: PACTR201105000286876

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