Last Updated: 31/01/2025

An integrated approach to clinical trials, capacity building and networking in West Africa (WANECAM)

Objectives

The primary objective of this clinical study was to compare the incidence rate of uncomplicated malaria episodes in children and adults treated with repeated ACT therapy over a period of two years. In this three arm study PA and DHA-PQP is compared to either ASAQ or AL (depending on the site location).

The secondary objectives of this study were:

To compare PCR corrected and uncorrected ACPR at D28 and D42 (as defined by WHO 2009 protocol) between the ACT treatment arms
To compare re-infection and recrudescence rates over 42 days between the ACT treatment arms
To compare FCT and PCT between the ACT treatment arms
To compare gametocytes carriage and density between the ACT treatment arms
To compare time to the second infection and re-infections between treatments arms
To assess and compare safety of the three ACTs in repeated therapy.

Principal Institution

Malaria Research and Training Center (MRTC), University of Sciences, Techniques and Technologies of Bamako (USTTB), Mali

Principal Investigators / Focal Persons

Abdoulaye Djimde

Partner Institutions

National Center for Training and Research in Rural Health (CNFRSR), Guinea
Karolinska Institute (KI), Sweden
University of Heidelberg, Germany
London School of Hygiene and Tropical Medicine (LSHTM), United Kingdom
National Center for Research and Training for Malaria (CNRFP) Burkina Faso, Burkina Faso

Research Institute of Health Sciences (IRSS), Burkina Faso
University of Lyon, France