Discovery of anti-malarial lead compounds in Xisha sponge and soft coral

Malaria is one of the ancient and neglected parasitic infectious diseases. Since failure to control malaria is the emergence and spread of resistance to first-line antimalarial drugs, finding new and efficient antimalaria leading compounds is the primary work for treatment of malaria. The extract of Acanthella cavernosa and Sinularia sp. showed significant antimalaria activity against Plasmodium falciparum. The isolation of kalihinenes and cembranes was by bioassay, UV and NMR guided, single crystal X-ray diffraction, CD spectrum and DFT or TD-DFT were used to determine the absolute structures. The structure activity relationship was investigated to find one or more antimalaria leading compounds.

Basic Science
Drug-based Strategies

Jan 2015 — Dec 2017

$39,777

China