Last Updated: 07/05/2026
Molecular mechanisms of non specific T cell response upon malaria
Objectives
This project investigates the nonspecific activation and suppression of T cell responses during malaria infection, highlighting that this atypical immune response can be inhibited by blocking ATP release from red blood cells.
Specificity is the most important in the immune system, and if this immunological rule is violated, immune cells that are unrelated to the pathogen become activated upon infection. It was found that in malaria infection, the immune response is nonspecifically activated and suppressed. This characteristic T cell response was inhibited by blocking ATP release from red blood cells. Furthermore, it has been suggested that adenosine, which is a metabolite of ATP, suppresses the immune response nonspecifically.
Apr 2015 — Mar 2019
$44,022
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