Last Updated: 02/12/2025

Analysis of parasitophorous vacuole membrane protein in hemoglobin transport and metabolism of malarial parasites

Objectives

*Original title and text were machine translated from Japanese

This study investigated the parasitophorous vacuole membrane (PVM) protein (ETRAMP family) of P. falciparum and analyzed the localization in the membrane structure involved in hemoglobin transport.

Principal Institution

Kobe University, Japan

Principal Investigators / Focal Persons

Hideyuki Iriko

Rationale and Abstract

Plasmodium parasites on erythrocytes utilize hemoglobin as a source of amino acid. Uptake and transport of hemoglobin by malarial parasites are carried out through parasitophorous vacuole membrane (PVM), but the molecular mechanism has not been elucidated. In the result, ETRAMP10.3 was found to be localized to the PVM, cytostorm and hemoglobin transport vesicles, and to be an indicator of hemoglobin transport during gametocyte stage.

External reference

Project details

Themes

Basic Science

Date

Apr 2016 — Mar 2019

Total Project Funding

$42,366

Funding Details

Japan Society for the Promotion of Science (JSPS), Japan

Grant ID: 16K08760

JPY 4.68M