Last Updated: 26/11/2025
Mass administration of antimalarials and targeted control of carriage to reduce the transmission of Plasmodium in the Sahel (AMARETi)
Objectives
This project proposes to co-design, implement, and evaluate an intervention to combat this asymptomatic carriage through a village-level randomized clinical trial. The first approach will be to conduct a mass drug administration (MDA) campaign to treat as many asymptomatic carriers as possible at the beginning and end of the high transmission season. The second approach will be to co-design targeted activities with and for young adults.
In the Sahel, WHO-recommended malaria control interventions aim to reduce the clinical burden of malaria (particularly severe cases and deaths) and to control mosquitoes, the vectors of transmission. In the Kédougou region of Senegal, these interventions have been deployed with appropriate coverage for approximately 10 years. Despite a significant decrease, malaria transmission persists due to a reservoir of asymptomatic carriers. The hypothesis is that targeting this asymptomatic reservoir will effectively complement current interventions and further reduce transmission. The project addresses the need for new strategies to combat seasonal malaria. It also responds to an operational request from Senegal’s National Malaria Control Program (PNLP), which wishes to implement AMA to progress towards its elimination goal.
Jul 2024 — Aug 2028
$2.66M
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