Last Updated: 03/10/2025

Functional analysis of RON11 and its signal transduction pathway in different invasive forms of malaria parasites

Objectives

This project focus on Rhoptry Neck Protein 11 (RON11), a rhoptry molecule that has a calcium-binding domain and is localized on the rhoptry membrane, and aim to elucidate how the signal transduction pathway mediated by RON11 is involved in the secretion of rhoptry proteins by identifying interacting proteins.

Principal Institution

Tokyo University of Science (TUS), Japan
Institute of Science Tokyo, Japan

Principal Investigators / Focal Persons

Yuto Kegawa

Rationale and Abstract

Malaria parasites that infect hepatocytes and those that infect erythrocytes share a group of secretory proteins derived from the rhoptry, a cell organelle specific to the parasite. It is extremely important for host cell parasitism that rhoptry proteins are secreted in the appropriate order and timing upon cell invasion, but the mechanism of secretion has not yet been elucidated.

External reference

Project details

Themes

Basic Science

Date

Apr 2025 — Mar 2027

Total Project Funding

$31,756

Funding Details

Japan Society for the Promotion of Science (JSPS), Japan

Grant ID: 25K18787

JPY 4.81M