Last Updated: 01/10/2025
Structural and biochemical analysis of Plasmodium falciparum nucleosomes
Objectives
This study aims to clarify the epigenetic transcriptional control mechanism of Plasmodium falciparum based on chromatin structure.
The specific objectives of this study are to:
- reconstitute nucleosomes containing specific histones of Plasmodium falciparum using in vitro reconstitution techniques; and
- clarify the specific biochemical properties and three-dimensional structure of Plasmodium falciparum nucleosomes by biochemical and cryo-electron microscopy analysis.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
Plasmodium falciparum, the pathogen of malaria, proliferates in the human body by evading the human immune system. This evasion of the immune system is achieved by ingeniously controlling the expression of multiple genes of Plasmodium falciparum that are targets of the human immune system.
External reference
Date
Apr 2024 — Mar 2027
Total Project Funding
$30,043
Funding Details
Project Site
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