Last Updated: 28/03/2025

Development of the method for functional screening of RIFIN

Objectives

*Original title and text were machine translated from Japanese.

In this study, the aim is to construct a library that artificially expresses all RIFIN genes, and then screen for interactions with immunosuppressive receptors to identify target receptors for all RIFINs.

Principal Institution

Osaka University (OU), Japan

Principal Investigators / Focal Persons

Shiroh Iwanaga

Rationale and Abstract

Plasmodium falciparum is the most pathogenic parasite to humans, causing hundreds of thousands of deaths annually due to fever, splenomegaly, and severe coma. When the parasite infects host red blood cells, it transports and expresses RIFIN on the surface of the infected red blood cells, thereby suppressing the function of host immune cells. This study will provide clues to fully understand the immune evasion mechanism used by the parasite.

External reference

Project Details

Themes

Genetics and Genomics
Immunology

Date

Jun 2024 — Mar 2026

Total Project Funding

$42,929

Funding Details

Japan Society for the Promotion of Science (JSPS), Japan

JPY 6.5M

Project Site