Last Updated: 17/06/2026
Optimisation of a potent and fast acting antimalarial class that is orally efficacious in vivo
Objectives
This project aims to to further develop an identified highly active antimalarial series to meet the prerequisites required for partnership with the Medicines for Malaria Venture (MMV) for progression into the clinic.
Principal Institution
Walter and Eliza Hall Institute of Medical Research (WEHI), Australia
Principal Investigators / Focal Persons
Partner Investigators
Rationale and Abstract
Malaria is a devastating disease that results in 600 000 deaths annually. Current therapeutics used to combat malaria have a limited duration of use in the clinic due to the onset of resistance.
Project Outputs
- · Article: 7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc1 Complex - [ACS Infect. Dis, 2023]
- · Article: A review of natural products as a source of next-generation drugs against apicomplexan parasites - [npj Antimicrob Resist, 2025]
- · Article: Characterizing the quick-killing mechanism of action of azithromycin analogs against malaria parasites - [Antimicrob Agents Chemother, 2025]
- · Article: Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b - [Eur J Med Chem, 2024]
- · Article: Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4 - [ChemMedChem, 2024]
- · Article: Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3 - [Eur J Med Chem, 2024]
- · Article: Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4 - [J Med Chem, 2024]
External reference
Date
Jan 2018 — Dec 2019
Total Project Funding
$493,027
Funding Details
National Health and Medical Research Council (NHMRC) Australia, Australia
Grant ID: 1135421
AUD 683,916
Country / Project Site(s)
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