Last Updated: 04/06/2024
DNA topoisomerase VI: a novel target for herbicides and antimalarial drugs
Objectives
This project aims to characterise the enzyme, DNA topoisomerase VI and learn more about the reactions that it catalyses and its role in plants and plasmodia. This will be followed by the development of inhibitors of the enzyme by screening libraries of compounds and investigate the mechanism of action of compounds that are found to inhibit the enzyme and ultimately develop new leads for herbicides and antimalarial therapy.
University of East Anglia (UEA), United Kingdom
Syngenta United Kingdom, United Kingdom
DNA topoisomerase VI is an enzyme that was originally discovered in archaea but has more recently been found in plants (Arabidopsis thaliana) and malaria parasites (Plasmodium falciparum). Rather little is known about this enzyme but it has key roles in plant growth and development and in the plasmodium life cycle.
Sep 2018 — Dec 2022
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