Last Updated: 18/06/2024
Gliding motility in malaria parasites during erythrocyte invasion
Objectives
*Original title and abstract were machine translated from Japanese
This study will identify the activation mechanism of merozoite gliding motility involved in initial adhesion, identify protozoan molecules and erythrocyte molecules involved in gliding motility and erythrocyte deformation, elucidate the signal transduction mechanism of gliding motility, and identify novel inhibitors.
Plasmodium, the pathogen of malaria, infects host red blood cells and exhibits lethal pathogenicity. This study focuses on the applicant’s recent discovery of the “gliding movement” of malaria parasites during the erythrocyte invasion stage, and elucidates the molecular mechanisms behind the gliding movement of malaria merozoites and the movement of erythrocyte deformation during erythrocyte adhesion. At the same time, we will create new targets and seeds for overcoming malaria will be created by finding inhibitors for gliding movement. When the malaria parasite invades erythrocytes, it induces a deformation of the erythrocyte membrane called initial adhesion, and at this time, the parasite molecules interact with host molecules, which is thought to activate the parasite molecules for erythrocyte invasion.
Apr 2019 — Mar 2023
$38,484
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