Last Updated: 19/06/2024

Analysis of cell adhesion mechanism in infected erythrocytes during the reproductive maternal stage of Plasmodium falciparum

Objectives

*Original title and abstract were machine translated from Japanese.

This study attempts to identify adhesion molecules expressed on the surface of erythrocytes infected with gonads, with the aim of elucidating the molecular basis of the phenomenon of isolation of immature gonads from the bloodstream of infected individuals.

Principal Institution

Kobe University, Japan

Principal Investigators / Focal Persons

Hideyuki Iriko

Rationale and Abstract

The reproductive maternal part of Plasmodium falciparum is an essential stage for sexual reproduction in mosquitoes. In the infected body, the immature reproductive mother is isolated in the bone marrow parenchyma, but when it matures, it is released into the bloodstream and waits for several days to freely circulate and be taken up by mosquitoes. This phenomenon is thought to be caused by the alteration of the properties of infected erythrocytes by protozoan proteins.

External reference

Project details

Themes

Basic Science

Date

Apr 2022 — Mar 2025

Total Project Funding

$35,000

Funding Details

Japan Society for the Promotion of Science (JSPS), Japan

Grant ID: 22K07040

JPY 4.16M