Last Updated: 19/12/2024
Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health (COSMIC)
Objectives
The aim of this proposal is to determine the added value (as compared to IPTp/SP alone implemented in health facilities) of community SST of pregnant women implemented through the CHW involved in HMM.
This aim will be achieved through:
- Identify bottlenecks for implementation by CHW involved in HMM of SST
- Determine the impact of introducing SST in pregnancy on quality of HMM
- Determine the impact of SST on ANC attendance and IPTp/SP coverage
- Determine the impact of SST on LBW, anaemia and placental malaria
- Estimate cost-effectiveness of SST as compared to IPTp/SP alone
- Formulate recommendations for possible implementation of the intervention
Institute of Tropical Medicine (ITM) Antwerp, Belgium
Centre Muraz, Burkina Faso
Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine, The Gambia
Medical Research Council (MRC), United Kingdom
Imperial College London, United Kingdom
World Health Organization (WHO), Switzerland
Pregnant women are very susceptible to malaria infection and Malaria in Pregnancy (MiP) is a major cause of maternal anaemia and low birth weight (LBW) that leads to infant mortality, poor growth and development. In low transmission areas, malaria can become severe, resulting in maternal and foetal death. In sub-Saharan Africa (SSA) MiP is responsible for 8–14% of LBW, 3–8% of infant deaths, higher risk of post-partum haemorrhage and >10,000 maternal deaths/year. Prevention like, bed nets and intermittent preventive treatment with sulphadoxine-pyrimethamine (IPTp/SP), is cheap and cost-effective, but coverage achieved by these interventions is low.
ClinicalTrials.gov Identifier: NCT01941264
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Sep 2012 — May 2017
$4.95M
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