Last Updated: 03/03/2025
Structure guided design of a transmission-blocking malaria vaccine targeting Pfs48/45
Objectives
The main objective of this project is to characterize an important parasite surface protein and then testing of designed immunogens in a pre-clinical setting. The main objective will be achieved by structuring and shaping of Pfs48/45 and also understanding the location and the nature of the sites where the gamete-fusion-preventing antibodies bind. These newly designed molecules will form part of the malaria vaccines of the future.
Principal Institution
Principal Investigators / Focal Persons
Partner Institutions
Study Design
- Design novel molecules which contain just the regions of Pfs48/45 that are needed to bind to inhibitory antibodies with the latest computational tools.
- Inject mice with these novel immunogens and study the antibodies that are produced in a mosquito-infection experiment.
- Fed mosquitoes on human blood containing malaria parasites.
Project Outputs
External reference
Date
Oct 2017 — Sep 2020
Total Project Funding
$594,910
Funding Details
Medical Research Council (MRC), United Kingdom
Research Grants MR/R001138/1
Grant ID: MR/R001138/1
GBP 444,238
Project Site
Deep Dives
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