Novel Insecticides: structure activity relationships of a formamidine octopamine receptor agonist with mosquitocidal activity

Vector-borne diseases, especially those such as malaria and dengue fever have an enormous impact on the United States Military and human morbidity and mortality worldwide. Vector management has a proven track record in the control of insect-transmitted disease in human populations; unfortunately, the keystone of this control, insecticide treatment, is no longer effective in some areas due to development of resistance. The octopaminergic system is involved in a variety of essential insect physiological processes and is essentially absent in vertebrates, making this pathway an attractive target for insecticide development. The aim o this project will be achieved by  1) performing a structure activity relationship study to enhance stability, increase lipophilicity, and reduce mammalian toxicity; and 2) assess the physiological response of mosquitoes olfaction and behavior to formamidine analogs. 

Product Development
Vector Control

Jun 2016 — Jun 2018

$424,875

United States