Last Updated: 30/06/2024
An alternative strategy for fighting malaria drug resistance by causing reversal of resistance in malaria parasite population structure
Objectives
The objective of this project was to reverse the course of drug-resistant evolution, making drug-resistant malaria parasites drug-sensitive again through targeting fitness loss during the gain of malaria drug resistance.
Between 2000 and 2015, the number of new cases of malaria fell globally by 37% and in Africa by 42%. Malaria remains one of the most devastating infectious diseases in the world, with Plasmodium falciparum being the deadliest form of the malaria parasite. Artemisinin Combination Therapies (ACTs) are currently the front-line treatments against P. falciparum malaria but there is serious concern that malaria parasites are once again developing widespread resistance to this vital treatment.
Oct 2013 — Mar 2015
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