Multiplex assays of variant effects (MAVEs): Approaches, Analysis, and Interpretation
Wellcome Connecting Science offers a week-long residential course on Multiplex assays of variant effects (MAVEs): Approaches, Analysis, and Interpretation to learn how to analyse, assess, and interpret MAVE data for clinical and research applications.
Dates: 23-28 November 2025
Location: Hinxton, UK
Multiplex assays of variant effects (MAVEs) are a series of high throughput experimental methods used to interrogate the phenotypic or functional effects of thousands of genetic variants in parallel. They have rapidly increased our ability to assess variants of uncertain significance (VUS) where rare or unknown variants may be responsible for pathogenic disease-associated effects. Their recent adoption into clinical diagnostics provides additional evidence for variant interpretation and translation.
This course offers participants an opportunity to engage with an international team of MAVE experts, and gain insight into the generation, application, analysis, and interpretation and evaluation of MAVE data. Participants will learn how these assays are performed, how to access available tools and resources, and how utilise various analysis pipelines to determine and interpret variant effects according to the American College of Medical Genetics and Genomics (ACMG) framework.
What will this course cover?
This new addition to our programme will be delivered as a combination of seminars and discussions, interactive tutorials, and hands-on laboratory demonstrations and computer practical sessions which cover:
- Introduction to MAVEs and their applications
- How data is generated and the methods of experimentation
- Open Source tools, databases, and resources
- Quality control and analysis of MAVE data
- Evaluation and assessment of suitability of MAVE outputs
- Translation and interpretation of MAVE data in clinical settings
The course content will be delivered in English.
Who is this course for?
This course is open to postdoctoral scientists, advanced PhD students, clinicians or clinical scientists, interested in genetic variant interpretation and actively engaged in or soon to commence research or utilise MAVE and MAVE datasets in their work from anywhere in the world.
Cost and financial assistance:
- Course fee: £994, includes accommodation and all meals
- Reduced rates are available for those who do not require accommodation, please contact us for more information. Please be aware that the campus is based in a rural location and this option is only suitable for attendees who are already based locally and have access to private transport.
Bursaries
- Limited bursaries, covering up to 50% of the course fee, are awarded based on merit. To apply, complete the bursary section of the online application form, explaining why funding would benefit you.
- Applicants will be informed of the outcome, along with their course placement, typically within a month of the application deadline.
- Please note that both the applicant and sponsor are required to provide a justification for the bursary as part of the application.
Read more here
Application deadline, 18th of August 2025.
