GiveWell RFI Call for Malaria Pilot Programs and Research

GiveWell opens a call for new RFI for malaria pilot programs and research and evaluation.

Organization can apply through two submission tracks: 

  • Pilot programs focused on malaria chemoprevention and vector control across Africa
    • Category 1: antimalarial medicines
      • Perennial malaria chemoprevention (PMC)
      • Post-discharge malaria chemoprevention (PDMC)
      • Chemoprevention in school-aged children (IPTsc)
    • Category 2: vector control
      • Continuous net distribution – technical assistance 
      • Insecticide-treated net (ITN) social and behaviour change (SBC)

Find here more information on Pilot programs focused on malaria chemoprevention and vector control across Africa track.

  • Research and evaluation with potential to improve GiveWell’s future grantmaking in sub-Saharan Africa
    • Category 1: Improving our cost-effectivenes analysis
      • 1.1 What can we learn from recent, primary data on malaria burden and epidemiology in high-burden countries of Africa?
      • 1.2 What is the effectiveness and impact of seasonal malaria chemoprevention (SMC) in current implementation contexts?
      • 1.3 What is the effectiveness and impact of insecticide-treated net campaigns in current implementation contexts?
      • 1.4a What are the effects of malaria on all-cause mortality? (Mendelian randomization leveraging sickle cell trait)
      • 1.4b What are the effects of malaria on long-term individual income? (Mendelian randomization leveraging sickle-cell trait)
      • 1.5 What is the performance of malaria rapid diagnostic tests in implementation settings?
    • Category 2: Intervention research including randomized controlled trials
      • 2.1 Can alternative drug regimens improve the effectiveness or cost-effectiveness of SMC?
      • 2.2 Is weekly hydroxychloroquine a cost-effective addition to intermittent preventive treatment of malaria in pregnant women (IPTp)?
      • 2.3 Can single low-dose primaquine (SLDPQ) prevent transmission of artemisinin-resistant malaria?
      • 2.4 What is the impact of spatial emanators on malaria burden in high-burden settings?
    • Catergory 3: Optimizing delivery of existing programs.
      • 3.1 Optimizing delivery of seasonal malaria chemoprevention (SMC) 
      • 3.2 Monitoring the effects of ITN mass campaign cost-cutting 
      • 3.3 ITN and SMC mass campaign co-delivery

Find here more information on Research and evaluation with potential to improve GiveWell’s future grantmaking in sub-Saharan Africa track.

Eligibility: 

Pilot programs focused on malaria chemoprevention and vector control across Africa.

  • Large non-governmental organizations (NGOs) that are currently active in malaria program implementation or evaluation
  • Smaller or local NGOs with demonstrated implementation capacity and experience in the proposed geographic setting
  • Academic institutions or research groups, particularly those partnering with an implementing organization
  • Large multilateral organizations with relevant expertise
  • Organizations currently implementing malaria programs that are interested in adding a rigorous evaluation component

Joint proposals from consortia representing multiple institutions are welcome.

For logistical reasons, GiveWell is unable to fund Ministries of Health (MoHs) directly through this RFI; however, MoH staff can be included as collaborators on projects led by other organizations.

Informative webinars:

  • Pilot program track –  May 15 at 9:00am ET
  • Research and evaluation track – May 18 at 9:00am ET

Application deadline, 3 July 2026 at 5pm EDT.

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