Last Updated: 17/08/2026
Understanding and controlling trace metal homeostasis in malaria parasites
Objectives
*Original title and text were machine translated from Japanese.
In this research project, a low-molecular compound will be independently designed and synthesized that exhibits an affinity interaction with zinc, which is necessary for the life activities of malaria parasites.
Then, by using these compounds, a breakdown in zinc homeostasis will be artificially induced and analyze the effects on the proliferation activity and morphological changes of malaria parasites. Furthermore, by conducting gene expression analysis of malaria parasites, the aim is to elucidate part of the molecular mechanism governing zinc homeostasis, thereby obtaining useful knowledge that will contribute to the research and development of new malaria therapeutics.
Apr 2023 — Mar 2026
$34,916
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