The mechanism of erythrocyte invasion by malaria parasites through proteomics of secretory organelles

Objectives

This study aims to fully elucidate the molecular mechanism of erythrocyte invasion by malaria parasites.

The specific objectives are to:

1. comprehensively analyze the secretory proteins contained in secretory organelles involved in erythrocyte invasion by introducing the proximity-dependent biotin labeling method, one of the latest technologies; and
2. perform functional analysis of the novel secretory factors obtained, aiming to elucidate the comprehensive mechanism of erythrocyte infection through the spatiotemporal control of secretory organelle molecules and the cooperative action between organelles.